Membrane-targeting AM-0016 kills mycobacterial persisters and shows low propensity for resistance development
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چکیده
منابع مشابه
Boromycin Kills Mycobacterial Persisters without Detectable Resistance
Boromycin is a boron-containing polyether macrolide antibiotic isolated from Streptomyces antibioticus. It was shown to be active against Gram positive bacteria and to act as an ionophore for potassium ions. The antibiotic is ineffective against Gram negative bacteria where the outer membrane appears to block access of the molecule to the cytoplasmic membrane. Here we asked whether boromycin is...
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The bacterium that causes tuberculosis, Mycobacterium tuberculosis, possesses a rather unique outer membrane composed largely of lipids that possess long-chain and branched fatty acids, called mycolic acids. These lipids form a permeability barrier that prevents entry of many environmental solutes, thereby making these bacteria acid-fast and able to survive extremely hostile surroundings. Antit...
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BACKGROUND Limitations in treatment of biofilm-associated bacterial infections are often due to subpopulation of persistent bacteria (persisters) tolerant to high concentrations of antibiotics. Based on the increased aminoglycoside efficiency under alkaline conditions, we studied the combination of gentamicin and the clinically compatible basic amino acid L-arginine against planktonic and biofi...
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in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...
15 صفحه اولSepsis kills, antimicrobial resistance is real.
Doshi highlights the danger of speeding new antibiotics to market without adequate testing. However, it is dangerous to question the threat from antimicrobial resistance, and such questions must not detract from the urgent need for new antimicrobial agents. The reduction in mortality from infections worldwide between 1990 and 2013 highlighted by the Global Burden of Disease study coincides with...
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ژورنال
عنوان ژورنال: Future Microbiology
سال: 2016
ISSN: 1746-0913,1746-0921
DOI: 10.2217/fmb-2015-0015